Cloned (Comment) | Organism |
---|---|
quantitative PCR analysis of gene expression in different tissues/cells, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 BBe cell | - |
Homo sapiens | - |
Caco-2 cell | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
macrophage | expression of 1alpha-hydroxylase is intimately associated with toll-like receptor, TLR, recognition of pathogens in macrophages | Homo sapiens | - |
additional information | 25OHD action involves localized extrarenal conversion to 1,25-dihydroxyvitamin D via tissue-specific expression of the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
1alpha-hydroxylase | - |
Homo sapiens |
25-hydroxyvitamin D-1alpha-hydroxylase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of 1alpha-hydroxylase is induced via toll-like receptor, TLR, recognition of pathogens in macrophages, but not in colonic cells, i.e. Caco-2 and BBe colonic cell lines. Colonic epithelial cells may require specific factors to initiate intracrine responses to vitamin D. | up |
General Information | Comment | Organism |
---|---|---|
additional information | 25OHD action involves localized extrarenal conversion to 1,25-dihydroxyvitamin D via tissue-specific expression of the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase. Expression of 1alpha-hydroxylase is intimately associated with toll-like receptor, TLR, recognition of pathogens in macrophages | Homo sapiens |
physiological function | mechanisms for involvement of 1alpha-hydroxylase in antimicrobial responses within different barrier tissues, overview | Homo sapiens |