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Literature summary for 1.14.15.18 extracted from

  • Lagishetty, V.; Chun, R.F.; Liu, N.Q.; Lisse, T.S.; Adams, J.S.; Hewison, M.
    1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines (2010), J. Steroid Biochem. Mol. Biol., 121, 228-233.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
quantitative PCR analysis of gene expression in different tissues/cells, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 BBe cell
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Homo sapiens
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Caco-2 cell
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Homo sapiens
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colon
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Homo sapiens
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macrophage expression of 1alpha-hydroxylase is intimately associated with toll-like receptor, TLR, recognition of pathogens in macrophages Homo sapiens
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additional information 25OHD action involves localized extrarenal conversion to 1,25-dihydroxyvitamin D via tissue-specific expression of the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase Homo sapiens
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Synonyms

Synonyms Comment Organism
1alpha-hydroxylase
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Homo sapiens
25-hydroxyvitamin D-1alpha-hydroxylase
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of 1alpha-hydroxylase is induced via toll-like receptor, TLR, recognition of pathogens in macrophages, but not in colonic cells, i.e. Caco-2 and BBe colonic cell lines. Colonic epithelial cells may require specific factors to initiate intracrine responses to vitamin D. up

General Information

General Information Comment Organism
additional information 25OHD action involves localized extrarenal conversion to 1,25-dihydroxyvitamin D via tissue-specific expression of the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase. Expression of 1alpha-hydroxylase is intimately associated with toll-like receptor, TLR, recognition of pathogens in macrophages Homo sapiens
physiological function mechanisms for involvement of 1alpha-hydroxylase in antimicrobial responses within different barrier tissues, overview Homo sapiens