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Literature summary for 1.14.15.18 extracted from

  • Schroeder, O.; Turak, S.; Daniel, C.; Gaschott, T.; Stein, J.
    Upregulation of 25-hydroxyvitamin D3-1alpha-hydroxylase by butyrate in Caco-2 cells (2005), World J. Gastroenterol., 11, 7136-7141.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.15.18

Activating Compound

Activating Compound Comment Organism Structure
additional information butyrate transiently upregulates enzyme expression 2.3fold Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
25-hydroxyvitamin D + NADPH + O2 Homo sapiens the enzyme is involved in the vitamin D signaling pathway in colonic epithelial cell differentiation by butyrate, mechanism, overview 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
additional information Homo sapiens both butyrate and 1alpha-25(OH)2D3 stimulate differentiation of Caco-2 cells, while 25(OH)2D3 has no impact on cell differentiation ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell intestinal cell line, both butyrate and 1alpha-25(OH)2D3 stimulate differentiation of Caco-2 cells, while 25(OH)2D3 has no impact on cell differentiation Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
25-hydroxyvitamin D + NADPH + O2
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 Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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 ?
25-hydroxyvitamin D + NADPH + O2 the enzyme is involved in the vitamin D signaling pathway in colonic epithelial cell differentiation by butyrate, mechanism, overview Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
additional information both butyrate and 1alpha-25(OH)2D3 stimulate differentiation of Caco-2 cells, while 25(OH)2D3 has no impact on cell differentiation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
25-hydroxyvitamin D3-1alpha-hydroxylase
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 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens