Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a target in cancer therapy and prevention | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
25-hydroxyvitamin D + NADPH + O2 | Homo sapiens | extra-renal functions of 1alpha-hydroxylase in vitamin D physiology, regulation, overview | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
additional information | Homo sapiens | functional analysis of vitamin D metabolism in cancer, locally synthesized 1,25(OH)2D3 may be inefficient in preventing tumor progression, mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
dendritic cell | - |
Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
additional information | altered expression of 1alpha-hydroxylase in different types of neoplasm including breast, prostate and colon cancers, autocrine/paracrine synthesis of 1,25(OH)2D3 is decreased in tumor cells and cell lines | Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
25-hydroxyvitamin D + NADPH + O2 | - |
Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
25-hydroxyvitamin D + NADPH + O2 | extra-renal functions of 1alpha-hydroxylase in vitamin D physiology, regulation, overview | Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
additional information | functional analysis of vitamin D metabolism in cancer, locally synthesized 1,25(OH)2D3 may be inefficient in preventing tumor progression, mechanism, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
1alpha-hydroxylase | - |
Homo sapiens |
25-hydroxyvitamin D-1alpha-hydroxylase | - |
Homo sapiens |
CYP27B1 | - |
Homo sapiens |
extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |