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Literature summary for 1.14.15.18 extracted from
- Response of the 5-flanking region of the human 25-hydroxyvitamin D 1alpha-hydroxylase gene to physiological stimuli using a transgenic mouse model (2005), J. Mol. Endocrinol., 34, 237-245.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | dietary calcium and vitamin D depletion induces the enzyme expression | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of a transgenic mouse line expressing 1501 bp of 58 flanking region together with 44 bp of 58 untranslated region of the human CYP27B1 gene fused to the firefly luciferase reporter gene, luciferase protein and mRNA for CYP27B1 are localized to proximal convoluted tubule cells of the kidney with highest levels in 2-week-old animals, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 25-hydroxyvitamin D + NADPH + O2 | Homo sapiens | regulation of enzyme expression in kidney proximal tubules, overview | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | proximal convoluted tubule | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 25-hydroxyvitamin D + NADPH + O2 | - |
Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
| 25-hydroxyvitamin D + NADPH + O2 | regulation of enzyme expression in kidney proximal tubules, overview | Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 25-hydroxyvitamin D 1alpha-hydroxylase | - |
Homo sapiens |
| CYP27B1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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