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Literature summary for 1.14.15.18 extracted from
- Conventional and tissue-specific inactivation of the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) (2003), J. Cell. Biochem., 88, 245-251.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 25-hydroxyvitamin D3 + NADPH + O2 | Mus musculus | final step of the activation of vitamin D | 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
CYP27B1 knockout mice, normal development when fed a 1alpha,25-dihydroxyvitamin D replacement or a high-calcium diet | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| renal cortex | highest activity in proximal tubule | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 25-hydroxyvitamin D3 + NADPH + O2 | - |
Mus musculus | 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
| 25-hydroxyvitamin D3 + NADPH + O2 | final step of the activation of vitamin D | Mus musculus | 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 25-hydroxyvitamin D-1alpha-hydroxylase | - |
Mus musculus |
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