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Literature summary for 1.14.15.18 extracted from

  • Bareis, P.; Kallay, E.; Bischof, M.G.; Bises, G.; Hofer, H.; Potzi, C.; Manhardt, T.; Bland, R.; Cross, H.S.
    Clonal differences in expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase, of 25-hydroxyvitamin D(3)-24-hydroxylase, and of the vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1alpha,25-dihydroxyvitamin D(3) (2002), Exp. Cell Res., 276, 320-327.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
1,25-Dihydroxycholecalciferol increases mRNA expression in highly differentiated cells like Caco-2/15 Homo sapiens
Epidermal growth factor i.e. EGF Homo sapiens
Epidermal growth factor increases mRNA expression in highly differentiated cells like Caco-2/15 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,25-Dihydroxycholecalciferol calcitriol; decreases mRNA expression in less differentiated cells like Caco-2/AQ and COGA-1A and -1E Homo sapiens
Epidermal growth factor decreases mRNA expression in less differentiated cells like Caco-2/AQ and COGA-1A and -1E; i.e. EGF Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O cytochrome P-450 enzyme Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
colonic carcinoma cell line cell line COGA Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
calcidiol + NADPH + O2 highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol Homo sapiens calcitriol + NADP+ + H2O calcitriol is identical with 1,25-dihydroxycholecalciferol ?

Synonyms

Synonyms Comment Organism
CYB27B1
-
 Homo sapiens