Cloned (Comment) | Organism |
---|---|
expressed in V79-CYP24 or OK (CCL-1840) cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A326G | the mutation converts human CYP24A1 from 25-hydroxyvitamin-D3 24-hydroxylase into 25-hydroxyvitamin-D3 23-hydroxylase, generating 1alpha,25-dihydroxyvitamin D3-26,23-lactone | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | C24-hydroxylation, the preferred pathway of human CYP24A1 | Homo sapiens | 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | C23-hydroxylation | Homo sapiens | 1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O | - |
? | |
additional information | 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) is a bifunctional enzyme capable of the 24-hydroxylation of 1alpha,25-dihydroxyvitamin D3, leading to the excretory form, calcitroic acid (calcitetrol), and 23-hydroxylation, culminating in 1alpha,25-dihydroxyvitamin D3-26,23-lactone | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
25-hydroxyvitamin D3-24-hydroxylase | - |
Homo sapiens |
CYP24A1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |