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Literature summary for 1.14.15.14 extracted from

  • Vasilevskaya, A.V.; Yantsevich, A.V.; Sergeev, G.V.; Lemish, A.P.; Usanov, S.A.; Gilep, A.A.
    Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism (2017), J. Steroid Biochem. Mol. Biol., 169, 202-209 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WPP3
-
-
Mycobacterium tuberculosis H37Rv P9WPP3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
Mycobacterium tuberculosis ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
?
farnesol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
Mycobacterium tuberculosis H37Rv ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
?
geraniol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
Mycobacterium tuberculosis ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
?
geraniol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
Mycobacterium tuberculosis H37Rv ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
?
geranylgeraniol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
Mycobacterium tuberculosis ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
?
geranylgeraniol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
Mycobacterium tuberculosis H37Rv ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
?
lauric acid + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
Mycobacterium tuberculosis ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
?
lauric acid + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
Mycobacterium tuberculosis H37Rv ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
?
additional information the fusion complex of cytochrome b5 and NADH-cytochrome b5 reductase reduces Cyp124 (reduction efficiency -12.9%). The electron transfer pair adrenodoxin/NADPH-adrenodoxin reductase has a similar efficiency for Cyp124 reduction (reduction efficiency -9.4%) as the fusion complex. Rat NADPH-cytochrome P450 reductase is less effective for Cyp124 reduction. The enzyme can oxidize provitamin D3 (7-dehydrocholesterol) and vitamin D3. The final product is different from 1alpha- and 25-hydroxyvitamin D3 Mycobacterium tuberculosis ?
-
?
additional information the fusion complex of cytochrome b5 and NADH-cytochrome b5 reductase reduces Cyp124 (reduction efficiency -12.9%). The electron transfer pair adrenodoxin/NADPH-adrenodoxin reductase has a similar efficiency for Cyp124 reduction (reduction efficiency -9.4%) as the fusion complex. Rat NADPH-cytochrome P450 reductase is less effective for Cyp124 reduction. The enzyme can oxidize provitamin D3 (7-dehydrocholesterol) and vitamin D3. The final product is different from 1alpha- and 25-hydroxyvitamin D3 Mycobacterium tuberculosis H37Rv ?
-
?
phytanic acid + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
Mycobacterium tuberculosis ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
?

Subunits

Subunits Comment Organism
? x * 48000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
CYP124
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 six-coordinate, low-spin form of cytochrome P450 with Soret region absorption maximum at 417 nm Mycobacterium tuberculosis