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Literature summary for 1.14.14.94 extracted from

  • Zhao, Z.; He, X.; Bi, Y.; Xia, Y.; Tao, N.; Li, L.; Ma, Q.
    Induction of CYP4F3 by benzene metabolites in human white blood cells in vivo in human promyelocytic leukemic cell lines and ex vivo in human blood neutrophils (2009), Drug Metab. Dispos., 37, 282-291.
    View publication on PubMed
Search for more literature for 1.14.14.94

Activating Compound

Activating Compound Comment Organism Structure
all-trans retinoic acid significantly induces expression of CYP4F3A at both mRNA and protein levels in cultured HL-60 cells Homo sapiens
Benzene induces CYP4F3 in human blood cells both in vivo and in vitro Homo sapiens
phenol significantly induces expression of CYP4F3A at both mRNA and protein levels in cultured and differentiated HL-60 cells, in the proerythroid cell line K-562, and ex vivo in human neutrophils Homo sapiens

Application

Application Comment Organism
additional information induction of CYP4F3 may play a role in the development of benzene hematotoxicity and serve as a biomarker of benzene exposure Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell promyelocytic leukemic cell line Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
leukocyte
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP4F3
-
 Homo sapiens
leukotriene B4 omega-hydroxylase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function is critical in the inactivation of leukotriene B4 in polymorphonuclear leukocytes with a -fold induction between 3 and 71 Homo sapiens