Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.94 extracted from

  • Kikuta, Y.; Mizomoto, J.; Strobel, H.W.; Ohkawa, H.
    Expression and physiological function of CYP4F subfamily in human eosinophils (2007), Biochim. Biophys. Acta, 1771, 1439-1445.
    View publication on PubMed
Search for more literature for 1.14.14.94

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00064
-
 leukotriene B4 pH 7.5, 37°C Homo sapiens
0.0961
-
 6-trans-leukotriene B4 pH 7.5, 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ a cytochrome P450 enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens CYP4F3A is expressed in human leukocytes and catalyzes the omega-hydroxylation of LTB4 (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eosinophil
-
 Homo sapiens
-
granulocyte
-
 Homo sapiens
-
leukocyte
-
 Homo sapiens
-
monocyte
-
 Homo sapiens
-
additional information CYP4F3A expression analysis, overview Homo sapiens
-
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
12-hydroxyeicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2 CYP4F3A Homo sapiens ?
-
 ?
6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 CYP4F3A Homo sapiens ?
-
 ?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 CYP4F3A is expressed in human leukocytes and catalyzes the omega-hydroxylation of LTB4 Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 CYP4F3A catalyzes the omega-hydroxylation of LTB4 Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2 CYP4F3A Homo sapiens ?
-
 ?
additional information CYP4F3A also catalyzes the omega-hydroxylation of epoxyeicosatrieonic acids Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CYP4F3
-
 Homo sapiens
CYP4F3A
-
 Homo sapiens
LTB4 omega-hydroxylase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Homo sapiens