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Literature summary for 1.14.14.94 extracted from

  • Kikuta, Y.; Kusunose, E.; Kusunose, M.
    Catalytic properties of two human leukotriene B4 omega-hydroxylase P450s (2002), Int. Congr. Ser., 1233, 139-142.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00064
-
leukotriene B4
-
Homo sapiens
0.0065
-
20-hydroxy-leukotriene B4
-
Homo sapiens
0.0142
-
12-hydroxy-5,8,10,14-eicosatetraenoic acid
-
Homo sapiens
0.0179
-
lipoxin B4
-
Homo sapiens
0.0409
-
12-hydroxystearate
-
Homo sapiens
0.0423
-
12-hydroxystearate
-
Homo sapiens
0.0556
-
6-trans-leukotriene B4
-
Homo sapiens
0.0582
-
lipoxin A4
-
Homo sapiens
0.06
-
leukotriene B4
-
Homo sapiens
0.0752
-
12-hydroxy-5,8,10,14-eicosatetraenoic acid
-
Homo sapiens
0.0961
-
6-trans-leukotriene B4
-
Homo sapiens
0.254
-
lipoxin A4
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Storage Stability

Storage Stability Organism
-70°C, rapid loss of activity Homo sapiens
-70°C, stable for 4 years Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
12-hydroxy-5,8,10,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ?
-
?
12-hydroxystearate + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ?
-
?
20-hydroxy-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ?
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ?
-
?
lipoxin B4 + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ?
-
?
additional information no activity with 20-hydroxy-leukotriene B4 and lipoxin B4 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
CYP4F2
-
Homo sapiens
CYP4F3
-
Homo sapiens
leukotriene B4 omega-hydroxylase
-
Homo sapiens
LTB4 omega-hydroxylase
-
Homo sapiens