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Literature summary for 1.14.14.94 extracted from
- Catalytic properties of two human leukotriene B4 omega-hydroxylase P450s (2002), Int. Congr. Ser., 1233, 139-142.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00064 | - |
leukotriene B4 | - |
Homo sapiens |  |
| 0.0065 | - |
20-hydroxy-leukotriene B4 | - |
Homo sapiens | |
| 0.0142 | - |
12-hydroxy-5,8,10,14-eicosatetraenoic acid | - |
Homo sapiens | |
| 0.0179 | - |
lipoxin B4 | - |
Homo sapiens | |
| 0.0409 | - |
12-hydroxystearate | - |
Homo sapiens | |
| 0.0423 | - |
12-hydroxystearate | - |
Homo sapiens | |
| 0.0556 | - |
6-trans-leukotriene B4 | - |
Homo sapiens | |
| 0.0582 | - |
lipoxin A4 | - |
Homo sapiens | |
| 0.06 | - |
leukotriene B4 | - |
Homo sapiens | |
| 0.0752 | - |
12-hydroxy-5,8,10,14-eicosatetraenoic acid | - |
Homo sapiens | |
| 0.0961 | - |
6-trans-leukotriene B4 | - |
Homo sapiens | |
| 0.254 | - |
lipoxin A4 | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme | Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, rapid loss of activity | Homo sapiens |
| -70°C, stable for 4 years | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 12-hydroxy-5,8,10,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| 12-hydroxystearate + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| 20-hydroxy-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| lipoxin B4 + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| additional information | no activity with 20-hydroxy-leukotriene B4 and lipoxin B4 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP4F2 | - |
Homo sapiens |
| CYP4F3 | - |
Homo sapiens |
| leukotriene B4 omega-hydroxylase | - |
Homo sapiens |
| LTB4 omega-hydroxylase | - |
Homo sapiens |
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