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Literature summary for 1.14.14.94 extracted from

  • Sumimoto, H.; Kusunose, E.; Gotoh, Y.; Kusunose, M.; Minakami, S.
    Leukotriene B4 omega-hydroxylase in rat liver microsomes: identification as a cytochrome P-450 that catalyzes prostaglandin A1 omega-hydroxylation, and participation of cytochrome b5 (1990), J. Biochem., 108, 215-221.
    View publication on PubMed
Search for more literature for 1.14.14.94

Inhibitors

Inhibitors Comment Organism Structure
CO
-
 Rattus norvegicus
leukotriene B4 substrate prostaglandin A1 Rattus norvegicus
prostaglandin A1
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 prostaglandin A1
-
 Rattus norvegicus
0.042
-
 leukotriene B4
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus inactivation of leukotriene B4, a mediator of inflammation (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 inactivation of leukotriene B4, a mediator of inflammation Rattus norvegicus (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 leukotriene B4 is identical with (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate Rattus norvegicus 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 20-hydroxy-prostaglandin A1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 enzyme contains cytochrome P-450 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.038
-
 prostaglandin A1
-
 Rattus norvegicus
0.043
-
 leukotriene B4 substrate prostaglandin A1 Rattus norvegicus