Application | Comment | Organism |
---|---|---|
medicine | the enzyme is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi. Because this enzyme is unique to fungi, it is a promising drug target in fungal pathogens of other eukaryotes | Curvularia lunata |
pharmacology | the enzyme is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi. Because this enzyme is unique to fungi, it is a promising drug target in fungal pathogens of other eukaryotes. By identifying selected derivatives of cinnamic acid as possible antifungal drugs, and CYP53 family enzymes as their targets, a potential inhibitor-target system for antifungal drugs is developed | Curvularia lunata |
Cloned (Comment) | Organism |
---|---|
His-tagged benzoate 4-monooxygenase is expressed in Escherichia coli C43(DE3) cells | Curvularia lunata |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-1-(4-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one | competitive inhibitor | Curvularia lunata |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Curvularia lunata | B8QM33 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Curvularia lunata |
Synonyms | Comment | Organism |
---|---|---|
CYP53A15 | - |
Curvularia lunata |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi. Because this enzyme is unique to fungi, it is a promising drug target in fungal pathogens of other eukaryotes | Curvularia lunata |
metabolism | the enzyme is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi | Curvularia lunata |