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Literature summary for 1.14.14.83 extracted from

  • Burlat, V.; Oudin, A.; Courtois, M.; Rideau, M.; St-Pierre, B.
    Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derive (2004), Plant J., 38, 131-141.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geraniol + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
-
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Catharanthus roseus Q8VWZ7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aerial tissue young Catharanthus roseus
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leaf
-
Catharanthus roseus
-
additional information the enzyme is expressed in almost all tissues, except for flower and fruit, in situ RNA tissue hybridization, overview. Tissue localization of the enzyme and related primary metabolic pathways, overview Catharanthus roseus
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phloem parenchym Catharanthus roseus
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phloem parenchyma cell
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Catharanthus roseus
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stem
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Catharanthus roseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geraniol + [reduced NADPH-hemoprotein reductase] + O2
-
Catharanthus roseus (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP76B6
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Catharanthus roseus
G10H
-
Catharanthus roseus
geraniol 10-hydroxylase
-
Catharanthus roseus

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
Catharanthus roseus

General Information

General Information Comment Organism
evolution the enzyme belongs to the cytochrome-P450 monooxygenase family Catharanthus roseus
metabolism the enzyme is catalyzing the first commited step to iridoid monoterpene biosynthesis and is involved in monoterpene indole alkaloid biosynthesis in specialized cells of the laticifer-idioblast system, overview Catharanthus roseus
physiological function the enzyme is catalyzing the first commited step to iridoid monoterpene biosynthesis and is involved in monoterpene indole alkaloid biosynthesis in specialized cells of the laticifer-idioblast system, overview Catharanthus roseus