Cloned (Comment) | Organism |
---|---|
expression in insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not inhibitory or very little effect: alpha-naphthoflavone, sulfaphenazole and tranylcypromine | Homo sapiens | |
troleandomycin | 0.01 mM, almost complete inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.09 | - |
taurochenodeoxycholate | pH 7.4, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lithocholate + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | hyodeoxycholate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | isofornm CYP3A4 is the only enzyme tested which is active towards bile acids taurochenodeoxycholate and lithocholate. The enzyme catalyzes an efficient 6alpha-hydroxylation of both taurochenodeoxycholic acid and lithocholic acid | Homo sapiens | ? | - |
? | |
taurochenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP3A4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | a strong correlation exists between 6alpha-hydroxylation of taurochenodeoxycholic acid, CYP3A levels and testosterone 6beta-hydroxylation. There is also a strong correlation between 6alpha-hydroxylation of lithocholic acid, CYP3A levels and testosterone 6beta-hydroxylation | Homo sapiens |