Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | not activated by 0.025 mM 2-naphthoflavone | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cimetidine | - |
Homo sapiens | |
diltiazem | - |
Homo sapiens | |
doxycycline | - |
Homo sapiens | |
erythromycin | - |
Homo sapiens | |
hydralazine | - |
Homo sapiens | |
ketoconazole | - |
Homo sapiens | |
additional information | not inhibited by lignocaine, pyrimethamine, dapsone, chloroquine, diazepam, norfloxacin, proguanil, cycloguanil, and 4-chlorophenylbiguanide | Homo sapiens | |
nifepidine | - |
Homo sapiens | |
oleandomycin | - |
Homo sapiens | |
Omeprazole | - |
Homo sapiens | |
primaquine | - |
Homo sapiens | |
tetracycline | - |
Homo sapiens | |
troleandomycin | - |
Homo sapiens | |
verapamil | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinine + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
tacrolimus + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP3A4 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000026 | - |
at pH 7.4 and 37°C | Homo sapiens | ketoconazole | |
0.0083 | - |
at pH 7.4 and 37°C | Homo sapiens | troleandomycin | |
0.017 | - |
at pH 7.4 and 37°C | Homo sapiens | doxycycline | |
0.018 | - |
at pH 7.4 and 37°C | Homo sapiens | Omeprazole | |
0.02 | - |
at pH 7.4 and 37°C | Homo sapiens | primaquine | |
0.029 | - |
at pH 7.4 and 37°C | Homo sapiens | tetracycline | |
0.038 | - |
at pH 7.4 and 37°C | Homo sapiens | nifepidine | |
0.061 | - |
at pH 7.4 and 37°C | Homo sapiens | erythromycin | |
0.064 | - |
at pH 7.4 and 37°C | Homo sapiens | verapamil | |
0.097 | - |
at pH 7.4 and 37°C | Homo sapiens | cimetidine | |
0.127 | - |
at pH 7.4 and 37°C | Homo sapiens | diltiazem | |
0.143 | - |
at pH 7.4 and 37°C | Homo sapiens | oleandomycin | |
0.197 | - |
at pH 7.4 and 37°C | Homo sapiens | hydralazine |