Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-naphthoflavone | 0.05 mM 2-naphthoflavone activates the enzyme (about 40%) in the presence of high substrate concentrations (0.5 mM) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-naphthoflavone | 0.05 mM 2-naphthoflavone is inhibitory (about 60%) in the presence of low substrate concentrations (0.1 mM) | Homo sapiens | |
erythromycin | about 45% inhibition at 0.01 mM | Homo sapiens | |
midazolam | specific inhibitor, about 25% inhibition at 0.01 mM | Homo sapiens | |
troleandomycin | about 95% inhibition at 0.01 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00083 | - |
Quinine | at pH 7.4 and 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinine + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP3A | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.11 | - |
midazolam | at pH 7.4 and 37°C | Homo sapiens |