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Literature summary for 1.14.14.55 extracted from

  • Zhang, H.; Coville, P.F.; Walker, R.J.; Miners, J.O.; Birkett, D.J.; Wanwimolruk, S.
    Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine (1997), Br. J. Clin. Pharmacol., 43, 245-252 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
2-naphthoflavone 0.05 mM 2-naphthoflavone activates the enzyme (about 40%) in the presence of high substrate concentrations (0.5 mM) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-naphthoflavone 0.05 mM 2-naphthoflavone is inhibitory (about 60%) in the presence of low substrate concentrations (0.1 mM) Homo sapiens
erythromycin about 45% inhibition at 0.01 mM Homo sapiens
midazolam specific inhibitor, about 25% inhibition at 0.01 mM Homo sapiens
troleandomycin about 95% inhibition at 0.01 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00083
-
Quinine at pH 7.4 and 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
quinine + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
quinine + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP3A
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.11
-
midazolam at pH 7.4 and 37°C Homo sapiens