Cloned (Comment) | Organism |
---|---|
expression of CYP3A4 in human B lymphoblastoid cell line AHH-1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
anti-CYP2C antibodies | inhibition of 20% | Homo sapiens | |
anti-CYP3A4 antibodies | inhibition of 72% | Homo sapiens | |
ketoconazole | maximum inhibition of 90% at 0.0005 mM | Homo sapiens | |
S-mephenytoin | maximum inhibition of 74% at 0.12 mM | Homo sapiens | |
troleandomycin | maximum inhibition of 70% at 0.08 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.046 | - |
Quinine | recombinant CYP2C19 | Homo sapiens | |
0.106 | - |
Quinine | between 0.08 mM and 0.145 mM in 10 different human livers | Homo sapiens | |
0.114 | - |
Quinine | recombinant CYP3A4 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinine + NADPH + O2 | - |
Homo sapiens | 3-hydroxyquinine + NADP+ + H2O | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00327 | - |
Quinine | recombinant CYP2C19 | Homo sapiens | |
0.125 | - |
Quinine | recombinant CYP3A4 | Homo sapiens |