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Literature summary for 1.14.14.32 extracted from

  • Kovacs, D.; Wölfling, J.; Szabo, N.; Szecsi, M.; Kovacs, I.; Zupko, I.; Frank, E.
    An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17alpha-hydroxylase/C17,20-lyase (2013), Eur. J. Med. Chem., 70, 649-660.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3beta-hydroxy-17-(50-[30-methyl]-10,20,40-oxadiazolyl)androst-5,16-diene compound displays in vitro cytotoxic activity against HeLa cells, MCF-7 cells, A-2780 cells and A-431 cells which are higher than or comparable to that of the reference cisplatin Homo sapiens
3beta-hydroxy-17-(50-[30-methyl]-10,20,40-oxadiazolyl)androst-5,16-diene
-
Rattus norvegicus
abiraterone
-
Rattus norvegicus
ketoconazole
-
Rattus norvegicus
O-3beta-acetoxyandrost-5,16-diene-17-acyl-p-methoxybenzamidoxime compound displays in vitro cytotoxic activity against HeLa cells, MCF-7 cells, A-2780 cells and A-431 cells which are higher than or comparable to that of the reference cisplatin Homo sapiens
O-3beta-acetoxyandrost-5,16-diene-17-acylacetamidoxime compound displays in vitro cytotoxic activity against HeLa cells, MCF-7 cells, A-2780 cells and A-431 cells which are higher than or comparable to that of the reference cisplatin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Rattus norvegicus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000012
-
pH 7.3, 37°C Rattus norvegicus abiraterone
0.000032
-
pH 7.3, 37°C Rattus norvegicus ketoconazole
0.00006
-
pH 7.3, 37°C Rattus norvegicus 3beta-hydroxy-17-(50-[30-methyl]-10,20,40-oxadiazolyl)androst-5,16-diene