Literature summary for 1.14.14.32 extracted from

Chen, C.F.; Wen, H.S.; Wang, Z.P.; He, F.; Zhang, J.R.; Chen, X.Y.; Jin, G.X.; Shi, B.; Shi, D.; Yang, Y.P.; Li, J.F.; Qi, B.X.; Li, N.
Cloning and expression of P450c17-I (17alpha-hydroxylase/17,20-lyase) in brain and ovary during gonad development in Cynoglossus semilaevis (2010), Fish Physiol. Biochem., 36, 1001-1012.

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Organism

Organism	UniProt	Comment	Textmining
Cynoglossus semilaevis	B2D2I4	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	predominantly present	Cynoglossus semilaevis	-
gill	weakly present	Cynoglossus semilaevis	-
intestine	weakly present	Cynoglossus semilaevis	-
kidney	weakly present	Cynoglossus semilaevis	-
additional information	weakly present in head kidney	Cynoglossus semilaevis	-
ovary	predominantly present	Cynoglossus semilaevis	-
spleen	weakly present	Cynoglossus semilaevis	-
stomach	weakly present	Cynoglossus semilaevis	-

Synonyms

Synonyms	Comment	Organism
17alpha-hydroxylase/17,20-lyase	-	Cynoglossus semilaevis
CYP17A1	-	Cynoglossus semilaevis
P450c17-I	-	Cynoglossus semilaevis

Expression

Organism	Comment	Expression
Cynoglossus semilaevis	in the brain, during the atretic follicles stage, the gene expression drops sharply to the lowest level	down
Cynoglossus semilaevis	CYP17A1 gene expression continuously rises throughout the ovarian development, except for a slight drop during the primary yolk stage. During the atretic follicles stage, the expression of CYP17A1 is remarkably upregulated and reaches the highest level. During the tertiary yolk stage, brain CYP17AI expression is 3.1fold higher than the primary yolk stage, and 4.4fold higher than that at atretic follicles stage	up

General Information

General Information	Comment	Organism
physiological function	critical role of P450c17-I during shift in steroidogenesis, important role during ovarian development	Cynoglossus semilaevis

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Release 2023.1 (January 2023)