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Literature summary for 1.14.14.32 extracted from

  • Hershkovitz, E.; Parvari, R.; Wudy, S.A.; Hartmann, M.F.; Gomes, L.G.; Loewental, N.; Miller, W.L.
    Homozygous mutation G539R in the gene for P450 oxidoreductase in a family previously diagnosed as having 17,20-lyase deficiency (2008), J. Clin. Endocrinol. Metab., 93, 3584-3588.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.32

Activating Compound

Activating Compound Comment Organism Structure
cytochrome b5
-
 Homo sapiens
additional information serine phosphorylation of P450c17 Homo sapiens
P450 oxidoreductase
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7alpha-hydroxypregnenolone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens 17,20-lyase activity 3beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7alpha-hydroxypregnenolone + [reduced NADPH-hemoprotein reductase] + O2 17,20-lyase activity Homo sapiens 3beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
17alpha-hydroxylase/17,20-lyase
-
 Homo sapiens
P450c17
-
 Homo sapiens