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Literature summary for 1.14.14.32 extracted from

  • Gupta, M.K.; Guryev, O.L.; Auchus, R.J.
    5alpha-reduced C21 steroids are substrates for human cytochrome P450c17 (2003), Arch. Biochem. Biophys., 418, 151-160.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0006
-
5alpha-pregnan-3alpha,17alpha-diol-20-one pH 7.4 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzyme, expression in Saccharomyces cerevisiae, enzyme catalyzes both 17alpha-hydroxylation of steroids, EC 1.14.99.9, and 17,20-lyase reaction
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxypregnenolone + ? + cytochrome b5
-
Homo sapiens dehydroepiandrosterone + ?
-
?
5alpha-pregnan-17alpha-ol-3,20-dione + ?
-
Homo sapiens androstanedione very little product formation ?
5alpha-pregnan-3alpha,17alpha-diol-20-one + ? + cytochrome b5 better substrate than 17alpha-hydroxypregenolone Homo sapiens androsterone + ? rapid reaction ?

Cofactor

Cofactor Comment Organism Structure
cytochrome b5 3fold stimulation of 17,20-lyase reaction of 5alpha-pregnan-3alpha,17alpha-diol-20-one Homo sapiens