Literature summary for 1.14.14.3 extracted from

Daghighi, S.; Sjollema, J.; Harapanahalli, A.; Dijkstra, R.J.; van der Mei, H.C.; Busscher, H.J.
Influence of antibiotic pressure on bacterial bioluminescence, with emphasis on Staphylococcus aureus (2015), Int. J. Antimicrob. Agents, 46, 713-717 .

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Application

Application	Comment	Organism
medicine	expression in Staphylococcus aureus Xen29. In the absence of antibiotics, staphylococcal bioluminescence increases over time until a maximum after ca. 6 h of growth, and subsequently decreases to the detection threshold after 24 h of growth. Up to minimal inhibitory concentrations of the antibiotics vancomycin, ciprofloxacin, erythromycin or chloramphenicol, bioluminescence increases according to a similar pattern up to 6 h of growth, but after 24 h, bioluminescence is higher than in the absence of antibiotics. Antibiotic pressure impacts the relation between bioluminescence per organism and bioluminescence. Under antibiotic pressure, bioluminescence is not controlled by luxA expression but by cofactors impacting the bacterial metabolic activity	Photorhabdus luminescens

Organism

Organism	UniProt	Comment	Textmining
Photorhabdus luminescens	-	-	-

Synonyms

Synonyms	Comment	Organism
LuxA	-	Photorhabdus luminescens

General Information

General Information	Comment	Organism
physiological function	expression in Staphylococcus aureus Xen29. In the absence of antibiotics, staphylococcal bioluminescence increases over time until a maximum after ca. 6 h of growth, and subsequently decreases to the detection threshold after 24 h of growth. Up to minimal inhibitory concentrations of the antibiotics vancomycin, ciprofloxacin, erythromycin or chloramphenicol, bioluminescence increases according to a similar pattern up to 6 h of growth, but after 24 h, bioluminescence is higher than in the absence of antibiotics. Antibiotic pressure impacts the relation between bioluminescence per organism and bioluminescence. Under antibiotic pressure, bioluminescence is not controlled by luxA expression but by cofactors impacting the bacterial metabolic activity	Photorhabdus luminescens

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Release 2023.1 (January 2023)