Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.3 extracted from

  • Kim, T.; Spiegel, D.
    Serendipitous discovery of two highly selective inhibitors of bacterial luciferase (2013), Tetrahedron, 69, 7692-7698.
No PubMed abstract available
Search for more literature for 1.14.14.3

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Vibrio harveyi

Inhibitors

Inhibitors Comment Organism Structure
1-Dodecanol
-
 Vibrio harveyi
1-Tetradecanol
-
 Vibrio harveyi
2,2-diphenylpropylamine
-
 Vibrio harveyi
8-Anilino-1-naphthalenesulfonate
-
 Vibrio harveyi
dodecanenitrile
-
 Vibrio harveyi
dodecylamine
-
 Vibrio harveyi
N,N-Dimethylaniline
-
 Vibrio harveyi
N-phenacylthiazolium bromide highly selective inhibition Vibrio harveyi
Pargyline
-
 Vibrio harveyi
pifithrin-alpha highly selective inhibitor in vivo and in vitro Vibrio harveyi
SKF-525A
-
 Vibrio harveyi
trans-2-decenal
-
 Vibrio harveyi
undecane
-
 Vibrio harveyi

Organism

Organism UniProt Comment Textmining
Vibrio harveyi
-
-
-
Vibrio harveyi BB120
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RCHO + FMNH2 + O2
-
 Vibrio harveyi RCOOH + FMN + H2O + hv
-
 ?
RCHO + FMNH2 + O2
-
 Vibrio harveyi BB120 RCOOH + FMN + H2O + hv
-
 ?

Synonyms

Synonyms Comment Organism
luciferase
-
 Vibrio harveyi
Lux
-
 Vibrio harveyi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00003
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi dodecylamine
0.00008
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi dodecanenitrile
0.000122
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi undecane
0.000356
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi 1-Tetradecanol
0.000482
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi 1-Dodecanol
0.005
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi trans-2-decenal
0.017
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi pifithrin-alpha
0.03
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi 8-Anilino-1-naphthalenesulfonate
0.09
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi SKF-525A
0.095
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi N-phenacylthiazolium bromide
0.1
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi N,N-Dimethylaniline
0.115
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi 2,2-diphenylpropylamine
1
-
 in 50 mM phosphate buffer, pH 7.0 at 23°C Vibrio harveyi Pargyline