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Literature summary for 1.14.14.29 extracted from
- Activation of pregnane X receptor induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apolipoprotein E deficient mice (2009), J. Lipid Res., 50, 2004-2010.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | mRNA encoding CYP39A1 gene is significantly repressed by pregnane X receptor activation in primary hepatocytes of wild-type mice but not in pregnane X receptor-/- hepatocytes | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cyp39a1 | - |
Mus musculus |
| oxysterol 7 alpha-hydroxylase | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | pregnane X receptor activation significantly regulates genes in the liver involved in lipoprotein transportation and cholesterol metabolism, including CYP39A1, in both wild-type and ApoE-/- mice | Mus musculus |
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