BRENDA - Enzyme Database show
show all sequences of 1.14.14.29

The enzymes, regulation, and genetics of bile acid synthesis

Russell, D.W.; Annu. Rev. Biochem. 72, 137-174 (2003)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Homo sapiens
5783
-
endoplasmic reticulum
-
Mus musculus
5783
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
58255
-
x * 58255, calculation from nucleotide sequence
Homo sapiens
58255
-
x * 58255, calculation from nucleotide sequence
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
Mus musculus
CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids
cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
-
?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
Mus musculus
CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids
cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
O75881
-
-
Mus musculus
Q60991
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
hepatic expression is induced during the third week of life and thereafter exhibits a sexually dimorphic expression pattern in this and other tissues in which expression is higher in the male
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
657550
Homo sapiens
cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
-
-
?
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
657550
Mus musculus
cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
-
-
?
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids
657550
Mus musculus
cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
-
-
?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
-
657550
Homo sapiens
cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
-
-
?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
-
657550
Mus musculus
cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
-
-
?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids
657550
Mus musculus
cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 58255, calculation from nucleotide sequence
Homo sapiens
?
x * 58255, calculation from nucleotide sequence
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
cytochrome P-450
-
Homo sapiens
cytochrome P-450
-
Mus musculus
NADPH
-
Homo sapiens
NADPH
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
cytochrome P-450
-
Homo sapiens
cytochrome P-450
-
Mus musculus
NADPH
-
Mus musculus
NADPH
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Homo sapiens
5783
-
endoplasmic reticulum
-
Mus musculus
5783
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
58255
-
x * 58255, calculation from nucleotide sequence
Homo sapiens
58255
-
x * 58255, calculation from nucleotide sequence
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
Mus musculus
CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids
cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
-
?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
Mus musculus
CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids
cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
hepatic expression is induced during the third week of life and thereafter exhibits a sexually dimorphic expression pattern in this and other tissues in which expression is higher in the male
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
657550
Homo sapiens
cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
-
-
?
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
657550
Mus musculus
cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
-
-
?
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids
657550
Mus musculus
cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
-
-
?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
-
657550
Homo sapiens
cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
-
-
?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
-
657550
Mus musculus
cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
-
-
?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids
657550
Mus musculus
cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 58255, calculation from nucleotide sequence
Homo sapiens
?
x * 58255, calculation from nucleotide sequence
Mus musculus
Other publictions for EC 1.14.14.29
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
726643
Roos
CYP7B1: novel mutations and ma ...
Homo sapiens
Acta Neurol. Scand.
129
330-334
2013
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4
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1
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711775
Arnoldi
Clinical phenotype variability ...
Homo sapiens
Clin. Genet.
81
150-157
2012
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1
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4
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2
2
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728174
Siam
Comparative modeling of 25-hyd ...
Homo sapiens
J. Mol. Model.
18
441-453
2012
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1
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3
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3
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695480
Burke
Hepatic bile acid metabolism i ...
Mesocricetus auratus
Am. J. Physiol. Gastrointest. Liver Physiol.
297
G144-G151
2009
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-
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3
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1
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1
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1
1
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-
699414
Diczfalusy
Marked upregulation of cholest ...
Mus musculus
J. Lipid Res.
50
2258-2264
2009
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2
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1
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1
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1
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702427
Pettersson
CYP7B1-mediated metabolism of ...
Homo sapiens, Mus musculus, Sus scrofa
Biochim. Biophys. Acta
1791
1206-1215
2009
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1
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3
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2
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7
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4
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8
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3
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1
3
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3
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5
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8
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3
3
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705003
Zhou
Activation of pregnane X recep ...
Mus musculus
J. Lipid Res.
50
2004-2010
2009
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1
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1
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1
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1
1
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684283
Tsaousidou
Sequence alterations within CY ...
Homo sapiens
Am. J. Hum. Genet.
82
510-515
2008
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1
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1
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686694
Pettersson
CYP7B1-mediated metabolism of ...
Homo sapiens, Sus scrofa
FEBS J.
275
1778-1789
2008
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4
2
1
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4
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2
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2
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4
2
2
1
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1
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4
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2
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689077
Wada
Identification of oxysterol 7a ...
Mus musculus
Mol. Pharmacol.
73
891-899
2008
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705397
Tang
Involvement of the PI3K/Akt pa ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
112
63-73
2008
1
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4
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2
1
1
2
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688678
Hennebert
Dehydroepiandrosterone 7alpha- ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
104
326-333
2007
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6
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689846
Olsson
Regulation and expression of h ...
Homo sapiens
Prostate
67
1439-1446
2007
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657550
Russell
The enzymes, regulation, and g ...
Homo sapiens, Mus musculus
Annu. Rev. Biochem.
72
137-174
2003
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2
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2
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659851
Ren
Regulation of oxysterol 7alpha ...
Rattus norvegicus
Metabolism
52
636-642
2003
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658874
Pandak William
Regulation of oxysterol 7alpha ...
Rattus norvegicus
Hepatology
35
1400-1408
2002
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657806
Martin
cyp7b1 catalyses the 7alpha-hy ...
Rattus norvegicus
Biochem. J.
355
509-515
2001
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5
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5
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3
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658818
Wu
Transcriptional regulation of ...
Homo sapiens
Gene
272
191-197
2001
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659142
Li-Hawkins
Disruption of the oxysterol 7a ...
Mus musculus
J. Biol. Chem.
275
16536-16542
2000
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