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Literature summary for 1.14.14.25 extracted from

  • Ramirez, D.M.; Andersson, S.; Russell, D.W.
    Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain (2008), J. Comp. Neurol., 507, 1676-1693.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP46A1, expressionin CHO-K1 cells and HEK-293 cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum dendritic Mus musculus 5783
-
microsome
-
Mus musculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ a cytochrome P450 enzyme Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Mus musculus the enzyme is required for learning and memory formation, mice deficient in CYP46A1 exhibit impaired learning and defective hippocampal long-term potentiation, overview (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
cerebellum cerebellar interneurons and Purkinje cells Mus musculus
-
cerebral cortex pyramidal neurons Mus musculus
-
dendritic cell
-
Mus musculus
-
hippocampus pyramidal neurons Mus musculus
-
additional information immunohistochemic analysis of enzyme distribution, overview Mus musculus
-
neuron
-
Mus musculus
-
Purkinje cell in the cerebellum Mus musculus
-
retina ganglion cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
Mus musculus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 the enzyme is required for learning and memory formation, mice deficient in CYP46A1 exhibit impaired learning and defective hippocampal long-term potentiation, overview Mus musculus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP46A1
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 a cytochrome P450 enzyme Mus musculus
NADPH
-
Mus musculus