Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.25 extracted from

  • Kotti, T.J.; Ramirez, D.M.; Pfeiffer, B.E.; Huber, K.M.; Russell, D.W.
    Brain cholesterol turnover required for geranylgeraniol production and learning in mice (2006), Proc. Natl. Acad. Sci. USA, 103, 3869-3874.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information brains from mice lacking 24-hydroxylase excrete cholesterol more slowly, and the tissue compensates by suppressing the mevalonate pathway, this suppression causes a defect in learning, 24-hydroxylase knockout mice exhibit severe deficiencies in spatial, associative, and motor learning, and in hippocampal long-term potentiation, the effects of genetic elimination of 24-hydroxylase on long-term potentiation are reversed by a 20-min treatment with geranylgeraniol but not by cholesterol, phenotype, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + reduced adrenodoxin + O2 Mus musculus enzyme deficiency leads to a suppression of the mevalonate pathway and a defect in learning 24-hydroxycholesterol + oxidized adrenodoxin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
hippocampus
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + reduced adrenodoxin + O2
-
Mus musculus 24-hydroxycholesterol + oxidized adrenodoxin + H2O
-
?
cholesterol + reduced adrenodoxin + O2 enzyme deficiency leads to a suppression of the mevalonate pathway and a defect in learning Mus musculus 24-hydroxycholesterol + oxidized adrenodoxin + H2O
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus