Literature summary for 1.14.14.23 extracted from

Noshiro, M.; Usui, E.; Kawamoto, T.; Kubo, H.; Fujimoto, K.; Furukawa, M.; Honma, S.; Makishima, M.; Honma, K.; Kato, Y.
Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis (2007), J. Biol. Rhythms, 22, 299-311.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q64505	wild-type and homozygous Clock mutant mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	expression profile of the Cyp7a transcript in wild-type mice shows a strong circadian rhythm in both the 12L:12D light-dark cycle and constant darkness. In Clock/Clock mutant mice expression profile of the Cyp7a transcript also exhibits a circadian rhythm at an enhanced level with a lower amplitude, although its protein level becomes arrhythmic at a high level. Active CLOCK is essential for the robust circadian expression of Cyp7a. Clock-controlled genes - DBP, DEC2, and REV-ERBalpha/beta are direct regulators required for the robust circadian rhythm of Cyp7a. The circadian rhythm of Cyp7a is regulated by multiple transcription factors, including DBP, REV-ERBalpha/beta, LXRalpha, HNF4alpha DEC2, E4BP4, and PPARalpha	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
cholesterol 7alpha-hydroxylase	-	Mus musculus
CYP7A	-	Mus musculus

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Release 2023.1 (January 2023)