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Literature summary for 1.14.14.19 extracted from

  • Stefanachi, A.; Favia, A.; Nicolotti, O.; Leonetti, F.; Pisani, L.; Catto, M.; Zimmer, C.; Hartmann, R.; Carotti, A.
    Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-alpha-hydroxylase/C17-20 lyase (2011), J. Med. Chem., 54, 1613-1625.
    View publication on PubMed
Search for more literature for 1.14.14.19

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-fluoro-4-[5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]phenol
-
 Homo sapiens
2-fluoro-4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]phenol
-
 Homo sapiens
3-[5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]pyridine
-
 Homo sapiens
3-[6-(4-fluorophenyl)-1H-inden-3-yl]pyridine
-
 Homo sapiens
4-(1H-imidazol-1-ylmethyl)-7-[(3-methylbenzyl)oxy]-2H-chromen-2-one
-
 Homo sapiens
4-(1H-imidazol-1-ylmethyl)-7-[[3-(trifluoromethyl)benzyl]oxy]-2Hchromen-2-one
-
 Homo sapiens
4-[5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]pyridine
-
 Homo sapiens
4-[5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]benzene-1,2-diol
-
 Homo sapiens
4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]benzene-1,2-diol
-
 Homo sapiens
4-[6-(3,4-difluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine
-
 Homo sapiens
4-[6-(3,4-difluorophenyl)-3,4-dihydronaphthalen-1-yl]pyridine
-
 Homo sapiens
4-[6-(4-fluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine
-
 Homo sapiens
4-[6-(4-fluorophenyl)-1H-inden-3-yl]pyridine
-
 Homo sapiens
4-[6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl]pyridine
-
 Homo sapiens
4-[6-(4-methoxyphenyl)-1H-inden-3-yl]pyridine
-
 Homo sapiens
5-(4-fluorophenyl)-1-(pyridin-3-yl)-2,3-dihydro-1H-inden-1-ol
-
 Homo sapiens
6-(3,4-difluorophenyl)-1-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
-
 Homo sapiens
6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
-
 Homo sapiens
7-[(3-chlorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one
-
 Homo sapiens
7-[(3-fluorobenzyl)oxy]-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
progesterone + reduced acceptor + O2 Homo sapiens
-
 17alpha-hydroxyprogesterone + acceptor + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
progesterone + reduced acceptor + O2
-
 Homo sapiens 17alpha-hydroxyprogesterone + acceptor + H2O
-
 ?

Synonyms

Synonyms Comment Organism
17-alpha-hydroxylase/C17-20 lyase
-
 Homo sapiens
CYP17
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function 17alpha-hydroxylase/C17,20-lyase, CYP17, a P450 enzyme, is responsible for catalyzing the final step in androgen biosynthesis Homo sapiens