Application | Comment | Organism |
---|---|---|
medicine | CYP17 inhibitors are synthesized for the potential treatment of prostate cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli cells | Homo sapiens |
gene CYp17, expression in Escherichia coli, coexpression with human cytochrome P450 reductase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole | - |
Homo sapiens | |
1-((9H-fluoren-2-yl)ethyl)-1H-imidazole | - |
Homo sapiens | |
1-((9H-fluoren-2-yl)methyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-(4'-(methylsulfanyl)biphenyl-4-yl)propyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-(4'-(trifluoromethoxy)biphenyl-4-yl)propyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-(4'-ethylbiphenyl-4-yl)propyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-(4'-fluorobiphenyl-4-yl)allyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-(4'-methylbiphenyl-4-yl)propyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-(biphenyl-4-yl)allyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-biphenyl-4-yl-2,2-dimethyl-propyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-biphenyl-4-yl-2-methyl-propyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-biphenyl-4-yl-2-phenyl-ethyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-biphenyl-4-yl-2-phenyl-methyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-biphenyl-4-yl-3-methyl-butyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-biphenyl-4-yl-butyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-biphenyl-4-yl-cyclohexyl-methyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-biphenyl-4-yl-pentyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-biphenyl-4-yl-propyl)-1H-imidazole | - |
Homo sapiens | |
1-(1-bis-biphenyl-4-yl-methyl)-1H-imidazole | - |
Homo sapiens | |
1-(2-(4'-fluorobiphenyl-4-yl)propan-2-yl)-1H-imidazole | - |
Homo sapiens | |
1-(3-(4'-fluorobiphenyl-4-yl)pentan-3-yl)-1H-imidazole | - |
Homo sapiens | |
1-(3-chloro-1-(4'-fluorobiphenyl-4-yl)propyl)-1H-imidazole | - |
Homo sapiens | |
1-(bis-biphenyl-4-yl-methyl)-1H-imidazole | - |
Homo sapiens | |
1-[1-(4'-fluoro-biphenyl-4-yl)-propyl]-1H-imidazole | - |
Homo sapiens | |
1-[1-(4'-fluoro-biphenyl-4-yl)propyl]-1H-imidazole | - |
Homo sapiens | |
1-[1-(7-fluoro-9H-fluoren-2-yl)-ethyl]-1H-imidazole | - |
Homo sapiens | |
1-[1-(7-fluoro-9H-fluoren-2-yl)ethyl]-1H-imidazole | - |
Homo sapiens | |
2-(1-(1H-imidazol-1-yl)ethyl)-7-fluoro-9H-carbazole | - |
Homo sapiens | |
2-(1-imidazol-1-yl-ethyl)-9H-carbazole | - |
Homo sapiens | |
3-(4'-fluorobiphenyl-4-yl)-3-(1H-imidazol-1-yl)propan-1-ol | - |
Homo sapiens | |
4'-(1-(1H-imidazol-1-yl)propyl)biphenyl-4-carbonitrile | - |
Homo sapiens | |
4'-(1H -imidazol-1-yl-propyl)-biphenyl-4-ol | - |
Homo sapiens | |
4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-ol | - |
Homo sapiens | |
4-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-morpholine | - |
Homo sapiens | |
7-(1-(1H-imidazol-1-yl)ethyl)-9H-fluoren-2-ol | - |
Homo sapiens | |
abiraterone | - |
Homo sapiens | |
diethyl-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-amine | - |
Homo sapiens | |
ketoconazole | - |
Homo sapiens | |
additional information | molecular modelling and docking studies, overview | Homo sapiens | |
N-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-acetamide | - |
Homo sapiens | |
[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-carbamic acid tert-butyl ester | - |
Homo sapiens | |
[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-dimethyl-amine | - |
Homo sapiens | |
[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-dimethylamine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + AH2 + O2 | Homo sapiens | - |
17alpha-hydroxypregnenolone + A + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
gene CYP17 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + AH2 + O2 | - |
Homo sapiens | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17alpha-hydroxylase-17,20-lyase | - |
Homo sapiens |
CYP17 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000072 | - |
abiraterone | - |
Homo sapiens | |
0.000099 | - |
7-(1-(1H-imidazol-1-yl)ethyl)-9H-fluoren-2-ol | - |
Homo sapiens | |
0.000112 | - |
1-((9H-fluoren-2-yl)ethyl)-1H-imidazole | - |
Homo sapiens | |
0.000118 | - |
2-(1-(1H-imidazol-1-yl)ethyl)-7-fluoro-9H-carbazole | - |
Homo sapiens | |
0.000168 | - |
1-[1-(7-fluoro-9H-fluoren-2-yl)ethyl]-1H-imidazole | - |
Homo sapiens | |
0.000282 | - |
2-(1-imidazol-1-yl-ethyl)-9H-carbazole | - |
Homo sapiens | |
0.0003 | - |
1-(1-biphenyl-4-yl-pentyl)-1H-imidazole | - |
Homo sapiens | |
0.00031 | - |
1-(1-biphenyl-4-yl-2-methyl-propyl)-1H-imidazole | - |
Homo sapiens | |
0.000345 | - |
1-[1-(4'-fluoro-biphenyl-4-yl)propyl]-1H-imidazole | - |
Homo sapiens | |
0.000375 | - |
4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-ol | - |
Homo sapiens | |
0.000388 | - |
1-((9H-fluoren-2-yl)methyl)-1H-imidazole | - |
Homo sapiens | |
0.00045 | - |
1-(1-biphenyl-4-yl-propyl)-1H-imidazole | - |
Homo sapiens | |
0.00046 | - |
1-(1-biphenyl-4-yl-2,2-dimethyl-propyl)-1H-imidazole | - |
Homo sapiens | |
0.00058 | - |
1-(1-biphenyl-4-yl-butyl)-1H-imidazole | - |
Homo sapiens | |
0.000756 | - |
1-(3-chloro-1-(4'-fluorobiphenyl-4-yl)propyl)-1H-imidazole | - |
Homo sapiens | |
0.00078 | - |
1-(1-biphenyl-4-yl-2-phenyl-ethyl)-1H-imidazole | - |
Homo sapiens | |
0.00079 | - |
1-(1-biphenyl-4-yl-2-phenyl-methyl)-1H-imidazole | - |
Homo sapiens | |
0.00105 | - |
1-(1-biphenyl-4-yl-cyclohexyl-methyl)-1H-imidazole | - |
Homo sapiens | |
0.0013 | - |
1-(3-(4'-fluorobiphenyl-4-yl)pentan-3-yl)-1H-imidazole | - |
Homo sapiens | |
0.0014 | - |
1-(1-(biphenyl-4-yl)allyl)-1H-imidazole | - |
Homo sapiens | |
0.0017 | - |
[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-carbamic acid tert-butyl ester | - |
Homo sapiens | |
0.002 | - |
1-(1-(4'-ethylbiphenyl-4-yl)propyl)-1H-imidazole | more than 0.002000 | Homo sapiens | |
0.0021 | - |
1-(1-biphenyl-4-yl-3-methyl-butyl)-1H-imidazole | - |
Homo sapiens | |
0.0022 | - |
4-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-morpholine | - |
Homo sapiens | |
0.0023 | - |
1-(1-bis-biphenyl-4-yl-methyl)-1H-imidazole | - |
Homo sapiens | |
0.00278 | - |
ketoconazole | - |
Homo sapiens | |
0.0031 | - |
1-(1-(4'-(methylsulfanyl)biphenyl-4-yl)propyl)-1H-imidazole | more than 0.003100 | Homo sapiens | |
0.0038 | - |
1-(2-(4'-fluorobiphenyl-4-yl)propan-2-yl)-1H-imidazole | - |
Homo sapiens | |
0.005 | - |
1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole | more than 0.005000 | Homo sapiens | |
0.005 | - |
1-(1-(4'-(trifluoromethoxy)biphenyl-4-yl)propyl)-1H-imidazole | more than 0.005000 | Homo sapiens | |
0.005 | - |
4'-(1-(1H-imidazol-1-yl)propyl)biphenyl-4-carbonitrile | more than 0.005000 | Homo sapiens | |
0.005 | - |
1-(1-(4'-methylbiphenyl-4-yl)propyl)-1H-imidazole | more than 0.005000 | Homo sapiens | |
0.005 | - |
diethyl-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-amine | more than 0.005000 | Homo sapiens | |
0.005 | - |
N-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-acetamide | more than 0.005000 | Homo sapiens | |
0.005 | - |
3-(4'-fluorobiphenyl-4-yl)-3-(1H-imidazol-1-yl)propan-1-ol | more than 0.005000 | Homo sapiens | |
0.005 | - |
1-(1-(4'-fluorobiphenyl-4-yl)allyl)-1H-imidazole | more than 0.005000 | Homo sapiens | |
0.005 | - |
[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-dimethyl-amine | more than 0.005000 | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000072 | - |
- |
Homo sapiens | abiraterone | |
0.000099 | - |
- |
Homo sapiens | 7-(1-(1H-imidazol-1-yl)ethyl)-9H-fluoren-2-ol | |
0.000112 | - |
- |
Homo sapiens | 1-((9H-fluoren-2-yl)ethyl)-1H-imidazole | |
0.000118 | - |
- |
Homo sapiens | 2-(1-(1H-imidazol-1-yl)ethyl)-7-fluoro-9H-carbazole | |
0.000168 | - |
- |
Homo sapiens | 1-[1-(7-fluoro-9H-fluoren-2-yl)-ethyl]-1H-imidazole | |
0.000282 | - |
- |
Homo sapiens | 2-(1-imidazol-1-yl-ethyl)-9H-carbazole | |
0.0003 | - |
- |
Homo sapiens | 1-(1-biphenyl-4-yl-pentyl)-1H-imidazole | |
0.00031 | - |
- |
Homo sapiens | 1-(1-biphenyl-4-yl-2-methyl-propyl)-1H-imidazole | |
0.000345 | - |
- |
Homo sapiens | 1-[1-(4'-fluoro-biphenyl-4-yl)-propyl]-1H-imidazole | |
0.000375 | - |
- |
Homo sapiens | 4'-(1H -imidazol-1-yl-propyl)-biphenyl-4-ol | |
0.000388 | - |
- |
Homo sapiens | 1-((9H-fluoren-2-yl)methyl)-1H-imidazole | |
0.00045 | - |
- |
Homo sapiens | 1-(1-biphenyl-4-yl-propyl)-1H-imidazole | |
0.00046 | - |
- |
Homo sapiens | 1-(1-biphenyl-4-yl-2,2-dimethyl-propyl)-1H-imidazole | |
0.00058 | - |
- |
Homo sapiens | 1-(1-biphenyl-4-yl-butyl)-1H-imidazole | |
0.000756 | - |
- |
Homo sapiens | 1-(3-chloro-1-(4'-fluorobiphenyl-4-yl)propyl)-1H-imidazole | |
0.00078 | - |
- |
Homo sapiens | 1-(1-biphenyl-4-yl-2-phenyl-ethyl)-1H-imidazole | |
0.00079 | - |
- |
Homo sapiens | 1-(1-biphenyl-4-yl-2-phenyl-methyl)-1H-imidazole | |
0.00105 | - |
- |
Homo sapiens | 1-(1-biphenyl-4-yl-cyclohexyl-methyl)-1H-imidazole | |
0.0013 | - |
- |
Homo sapiens | 1-(3-(4'-fluorobiphenyl-4-yl)pentan-3-yl)-1H-imidazole | |
0.0014 | - |
- |
Homo sapiens | 1-(1-(biphenyl-4-yl)allyl)-1H-imidazole | |
0.0017 | - |
- |
Homo sapiens | [4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-carbamic acid tert-butyl ester | |
0.002 | - |
- |
Homo sapiens | 1-(1-(4'-ethylbiphenyl-4-yl)propyl)-1H-imidazole | |
0.0021 | - |
- |
Homo sapiens | 1-(1-biphenyl-4-yl-3-methyl-butyl)-1H-imidazole | |
0.0022 | - |
- |
Homo sapiens | 4-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-morpholine | |
0.0023 | - |
- |
Homo sapiens | 1-(bis-biphenyl-4-yl-methyl)-1H-imidazole | |
0.00278 | - |
- |
Homo sapiens | ketoconazole | |
0.0031 | - |
- |
Homo sapiens | 1-(1-(4'-(methylsulfanyl)biphenyl-4-yl)propyl)-1H-imidazole | |
0.0038 | - |
- |
Homo sapiens | 1-(2-(4'-fluorobiphenyl-4-yl)propan-2-yl)-1H-imidazole | |
0.005 | - |
- |
Homo sapiens | 1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole | |
0.005 | - |
- |
Homo sapiens | 1-(1-(4'-(trifluoromethoxy)biphenyl-4-yl)propyl)-1H-imidazole | |
0.005 | - |
- |
Homo sapiens | 4'-(1-(1H-imidazol-1-yl)propyl)biphenyl-4-carbonitrile | |
0.005 | - |
- |
Homo sapiens | 1-(1-(4'-methylbiphenyl-4-yl)propyl)-1H-imidazole | |
0.005 | - |
- |
Homo sapiens | diethyl-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-amine | |
0.005 | - |
- |
Homo sapiens | N-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-acetamide | |
0.005 | - |
- |
Homo sapiens | 3-(4'-fluorobiphenyl-4-yl)-3-(1H-imidazol-1-yl)propan-1-ol | |
0.005 | - |
- |
Homo sapiens | 1-(1-(4'-fluorobiphenyl-4-yl)allyl)-1H-imidazole | |
0.005 | - |
- |
Homo sapiens | [4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-dimethylamine |