Protein Variants | Comment | Organism |
---|---|---|
additional information | reduced c-fos expression in polycystic ovary syndrome leads to reduced enzyme suppression, increased expression and activity resulting in increased androgen production | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | c-fos is an activator protein-1 transcription factor involved in the regulation of CYP17 expression in theca cells, tetradecanoylphorbol acetate increases c-fos 37fold leading to complete suppression of the enzyme, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is required for androgen production, genetic regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovary | - |
Homo sapiens | - |
theca folliculi | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is required for androgen production, genetic regulation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17alpha-hydroxylase | - |
Homo sapiens |
17alpha-hydroxylase 17,20 lyase | - |
Homo sapiens |
CYP17 | - |
Homo sapiens |