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Literature summary for 1.14.14.19 extracted from

  • Do Rego, J.L.; Tremblay, Y.; Luu-The, V.; Repetto, E.; Castel, H.; Vallarino, M.; Belanger, A.; Pelletier, G.; Vaudry, H.
    Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450C17) in the frog brain and pituitary (2007), J. Neurochem., 100, 251-268.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ketoconazole
-
Pelophylax lessonae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregnenolone + AH2 + O2 Pelophylax lessonae
-
17alpha-hydroxypregnenolone + A + H2O
-
?
progesterone + AH2 + O2 Pelophylax lessonae
-
17alpha-hydroxyprogesterone + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Pelophylax lessonae
-
-
-
Pelophylax lessonae
-
male frogs
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially from brain microsomes Pelophylax lessonae

Source Tissue

Source Tissue Comment Organism Textmining
brain telencephalon, diencephalon, mesencephalon, metencephalon. Immunoreactivity is almost exclusively located in neurons Pelophylax lessonae
-
brain distribution in the telencephalon, diencephalon, mesencephalon and metencephalon, detailed expression analysis, overview Pelophylax lessonae
-
diencephalon
-
Pelophylax lessonae
-
metencephalon
-
Pelophylax lessonae
-
pars distalis of pituitary Pelophylax lessonae
-
pars intermedia of pituitary Pelophylax lessonae
-
pituitary gland pars distalis, pars intermedia Pelophylax lessonae
-
pituitary gland in the pars distalis and pars intermedia of the pituitary, detailed expression analysis, overview Pelophylax lessonae
-
telencephalon
-
Pelophylax lessonae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pregnenolone + AH2 + O2
-
Pelophylax lessonae 17alpha-hydroxypregnenolone + A + H2O
-
?
progesterone + AH2 + O2
-
Pelophylax lessonae 17alpha-hydroxyprogesterone + A + H2O
-
?

Synonyms

Synonyms Comment Organism
cytochrome P450 17alpha-hydroxylase/C17,20-lyase
-
Pelophylax lessonae
P450c17
-
Pelophylax lessonae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
24
-
assay at Pelophylax lessonae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Pelophylax lessonae