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Literature summary for 1.14.14.19 extracted from

  • Owen, C.P.; Dhanani, S.; Patel, C.H.; Shahid, I.; Ahmed, S.
    Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)) (2006), Bioorg. Med. Chem. Lett., 16, 4011-4015.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(3,4-dichlorobenzyl)-1H-imidazole 50% inhibition of hydroxylase activity at 0.0122 mM, of 17,20-lyase activity at 0.0021 mM Rattus norvegicus
1-(3,5-dibromobenzyl)-1H-imidazole 50% inhibition of hydroxylase activity at 0.0259 mM, of 17,20-lyase activity at 0.00316 mM Rattus norvegicus
1-(3,5-dichlorobenzyl)-1H-imidazole 50% inhibition of hydroxylase activity at 0.0226 mM, of 17,20-lyase activity at 0.0033 mM Rattus norvegicus
1-(4-chlorobenzyl)-1H-imidazole 50% inhibition of hydroxylase activity at 0.0316 mM, of 17,20-lyase activity at 0.00281 mM Rattus norvegicus
1-(4-iodobenzyl)-1H-imidazole 50% inhibition of hydroxylase activity at 0.0110 mM, of 17,20-lyase activity at 0.00158 mM Rattus norvegicus
1-(4-nitrobenzyl)-1H-imidazole 50% inhibition of hydroxylase activity at 0.0254 mM, of 17,20-lyase activity at 0.0072 mM Rattus norvegicus
ketoconazole 50% inhibition of hydroxylase activity at 0.00376 mM, of 17,20-lyase activity at 0.00166 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
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Rattus norvegicus
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-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-