Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cytochrome b5 | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17-(1H-1,2,3-triazol-1-yl)androsta-4,16-dien-3-one | at 19 nM 50% inhibition, also potent inhibitor of 5alpha-reductase | Homo sapiens | |
17-(1H-1,2,3-triazol-1-yl)androsta-4,16-dien-3-one | at 9 nM 50% inhibition | Rattus norvegicus | |
17-(1H-1,2,4-triazol-1-yl)androsta-4,16-dien-3-one | at 55 nM 50% inhibition, also potent inhibitor of 5alpha-reductase | Homo sapiens | |
17-(1H-1,2,4-triazol-1-yl)androsta-4,16-dien-3-one | at 11 nM 50% inhibition | Rattus norvegicus | |
17-(1H-imidazol-1-yl)androsta-4,16-dien-3-one | at 7 nM 50% inhibition, also potent inhibitor of 5alpha-reductase | Homo sapiens | |
17-(1H-imidazol-1-yl)androsta-4,16-dien-3-one | at 8 nM 50% inhibition | Rattus norvegicus | |
3beta-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene | at 150 nM 94% inhibition | Homo sapiens | |
3beta-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene | at 10 nM 50% inhibition | Rattus norvegicus | |
3beta-hydroxy-17-(1H-1,2,4-triazol-1-yl)androsta-5,16-diene | at 150 nM 60% inhibition | Homo sapiens | |
3beta-hydroxy-17-(1H-1,2,4-triazol-1-yl)androsta-5,16-diene | at 26 nM 50% inhibition | Rattus norvegicus | |
3beta-hydroxy-17-(1H-imidazol-1-yl)androsta-5,16-diene | at 150 nM 97% inhibition | Homo sapiens | |
3beta-hydroxy-17-(1H-imidazol-1-yl)androsta-5,16-diene | at 9 nM 50% inhibition | Rattus norvegicus | |
ketoconazole | at 150 nM 67% inhibition | Homo sapiens | |
ketoconazole | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00056 | - |
17-hydroxypregnenolone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe3+ | - |
Homo sapiens | |
Fe3+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol | ? | - |
? | |
additional information | Rattus norvegicus | it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol | ? | - |
? | |
pregnenolone + AH2 + O2 | Rattus norvegicus | - |
17alpha-hydroxypregnenolone + A + H2O | - |
? | |
pregnenolone + AH2 + O2 | Homo sapiens | - |
17alpha-hydroxypregnenolone + A + H2O | cytochrome b5 also as cofactor | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Homo sapiens | - |
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol | Homo sapiens | ? | - |
? | |
additional information | it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol | Rattus norvegicus | ? | - |
? | |
pregnenolone + AH2 + O2 | - |
Rattus norvegicus | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
pregnenolone + AH2 + O2 | - |
Homo sapiens | 17alpha-hydroxypregnenolone + A + H2O | cytochrome b5 also as cofactor | ? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000012 | - |
3beta-hydroxy-17-(1H-imidazol-1-yl)androsta-5,16-diene | noncompetitive inhibitor | Homo sapiens | |
0.0000014 | - |
3beta-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene | noncompetitive inhibitor | Homo sapiens | |
0.0000019 | - |
17-(1H-imidazol-1-yl)androsta-4,16-dien-3-one | noncompetitive inhibitor | Homo sapiens | |
0.000023 | - |
3beta-hydroxy-17-(1H-1,2,4-triazol-1-yl)androsta-5,16-diene | noncompetitive inhibitor | Homo sapiens | |
0.000041 | - |
17-(1H-1,2,4-triazol-1-yl)androsta-4,16-dien-3-one | noncompetitive inhibitor | Homo sapiens | |
0.00008 | - |
17-(1H-1,2,3-triazol-1-yl)androsta-4,16-dien-3-one | noncompetitive inhibitor | Homo sapiens |