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Literature summary for 1.14.14.19 extracted from
- Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of P450 17 (1 alpha-hydroxylase/C17-20-lyase) (2001), Arch. Pharm., 334, 138-140.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3beta-hydroxy-23,24-bisnor-5-cholenic-hydroxamic acid | at 0.0025 mM 20% inhibition | Homo sapiens |  |
| 3beta-hydroxy-23,24-bisnor-5-cholenic-hydroxamic acid | at 0.125 mM 19% inhibition | Rattus norvegicus | |
| 3beta-hydroxy-5-androsten-17beta-hydroxamic acid | at 0.0025 mM 17% inhibition | Homo sapiens | |
| 3beta-hydroxy-5-androsten-17beta-hydroxamic acid | at 0.125 mM 18% inhibition | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
| progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| testis | - |
Homo sapiens | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
| progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| P450 17 | - |
Homo sapiens |
| P450 17 | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 32 | - |
- |
Rattus norvegicus |
| 37 | - |
- |
Homo sapiens |
| 37 | - |
- |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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