Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | oxidative stress and arsenite strongly induce HMOX1, heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1, BACH1 repression is dominant over NRF2-mediated HMOX1 transcription and inactivation of BACH1 is a prerequisite for HMOX1 induction, but nuclear accumulation of NRF2 is not necessary for HMOX1 induction | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | HO-1 gene regulation system, dynamic roles of transcriptional repressor BACH1 and transcription factor NRF2 in the transcription of the heme oxygenase-1 gene, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09601 | gene HMOX1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HaCaT cell | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | HO-1 gene regulation system, dynamic roles of transcriptional repressor BACH1 and transcription factor NRF2 in the transcription of the heme oxygenase-1 gene, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |