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Literature summary for 1.14.14.18 extracted from

  • Eipel, C.; Eisold, M.; Schuett, H.; Vollmar, B.
    Inhibition of heme oxygenase-1 protects against tissue injury in carbon tetrachloride exposed livers (2007), J. Surg. Res., 139, 113-120.
    View publication on PubMed
Search for more literature for 1.14.14.18

Activating Compound

Activating Compound Comment Organism Structure
additional information CCl4 induces HO-1 expression in the liver Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Sn-protoporphyrin SnPP-IX-mediated HO-1 inhibition markedly aggravates intrahepatic leukocyte-endothelial cell interaction with an almost 2fold increase of the number of adherent leukocytes when compared with solely CCl4-exposed livers Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Rattus norvegicus
-
 biliverdin + Fe2+ + CO + A + H2O
-
 ?
additional information Rattus norvegicus inhibition of heme oxygenase-1 protects against tissue injury in carbon tetrachloride exposed livers, SnPP-IX-mediated HO-1 inhibition markedly aggravates intrahepatic leukocyte-endothelial cell interaction with an almost 2fold increase of the number of adherent leukocytes when compared with solely CCl4-exposed livers, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P06762 female and male Sprague Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver parenchymal cells Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity in nonexposed control and SnPP-IX/CCl4-exposed liver tissue, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
 Rattus norvegicus biliverdin + Fe2+ + CO + A + H2O
-
 ?
additional information inhibition of heme oxygenase-1 protects against tissue injury in carbon tetrachloride exposed livers, SnPP-IX-mediated HO-1 inhibition markedly aggravates intrahepatic leukocyte-endothelial cell interaction with an almost 2fold increase of the number of adherent leukocytes when compared with solely CCl4-exposed livers, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
 Rattus norvegicus
HO-1
-
 Rattus norvegicus