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Literature summary for 1.14.14.18 extracted from

  • Naidu, S.; Wijayanti, N.; Santoso, S.; Kietzmann, T.; Immenschuh, S.
    An atypical NF-kappaB-regulated pathway mediates phorbol ester-dependent heme oxygenase-1 gene activation in monocytes (2008), J. Immunol., 181, 4113-4123.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the HO-1 gene is transcriptionally induced by the phorbol ester PMA in cell cultures of monocytic cells with a regulatory pattern that is different from that of LPS-dependent HO-1 induction in these cells, overview, the upregulation is abrogated in embryonic fibroblasts from p65-/- mice, antioxidant N-acetylcysteine and inhibitors of p38 MAPK or serine/threonine kinase CK2 also block the upregulating effect of PMA, thus induction of HO-1 gene expression by PMA is regulated via an IkappaB kinase-independent, atypical NFkappaB pathway that is mediated via the activation of p38 MAPK and CK2, overview, PMA-dependent HO-1 gene activation requires IkappaBalpha, but notIKK2 Mus musculus
additional information the HO-1 gene is transcriptionally induced by the phorbol ester PMA, mediated via a newly identified kappaB element of the proximal rat HO-1 gene promoter region, overview Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of the kappaB element of the proximal rat HO-1 gene promoter region, -284 to -275, a nuclear target for the NF-kappaB subunit p65/RelA, expression in in RAW264.7 monocytes fused to the luciferase gene. HO-1 promoter activity is induced by p65, an NF-kappaB subunit, which is also termed RelA, and which is a member of the Rel family of proteins and is activated in response to a variety of stimuli Mus musculus
expression of the kappaB element of the proximal rat HO-1 gene promoter region, -284 to -275, a nuclear target for the NF-kappaB subunit p65/RelA, expressionin in RAW264.7 monocytes fused to the luciferase gene Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Mus musculus HO-1 catalyzes the rate-limiting step of heme degradation and plays an important anti-inflammatory role via its enzymatic products carbon monoxide and biliverdin biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 Rattus norvegicus HO-1 catalyzes the rate-limiting step of heme degradation and plays an important anti-inflammatory role via its enzymatic products carbon monoxide and biliverdin biliverdin + Fe2+ + CO + A + H2O
-
?
additional information Mus musculus PMA-dependent activation of HO-1 is mediated via a nonclassical NF-kappaB pathway that is independent of IKK2 activity ?
-
?
additional information Rattus norvegicus PMA-dependent activation of HO-1 is mediated via a nonclassical NF-kappaB pathway that is independent of IKK2 activity ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P14901
-
-
Rattus norvegicus P06762
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte
-
Mus musculus
-
RAW-264.7 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2
-
Rattus norvegicus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 HO-1 catalyzes the rate-limiting step of heme degradation and plays an important anti-inflammatory role via its enzymatic products carbon monoxide and biliverdin Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 HO-1 catalyzes the rate-limiting step of heme degradation and plays an important anti-inflammatory role via its enzymatic products carbon monoxide and biliverdin Rattus norvegicus biliverdin + Fe2+ + CO + A + H2O
-
?
additional information PMA-dependent activation of HO-1 is mediated via a nonclassical NF-kappaB pathway that is independent of IKK2 activity Mus musculus ?
-
?
additional information PMA-dependent activation of HO-1 is mediated via a nonclassical NF-kappaB pathway that is independent of IKK2 activity Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Mus musculus
heme oxygenase-1
-
Rattus norvegicus
HO-1
-
Mus musculus
HO-1
-
Rattus norvegicus