Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the HO-1 gene is transcriptionally induced by the phorbol ester PMA in cell cultures of monocytic cells with a regulatory pattern that is different from that of LPS-dependent HO-1 induction in these cells, overview, the upregulation is abrogated in embryonic fibroblasts from p65-/- mice, antioxidant N-acetylcysteine and inhibitors of p38 MAPK or serine/threonine kinase CK2 also block the upregulating effect of PMA, thus induction of HO-1 gene expression by PMA is regulated via an IkappaB kinase-independent, atypical NFkappaB pathway that is mediated via the activation of p38 MAPK and CK2, overview, PMA-dependent HO-1 gene activation requires IkappaBalpha, but notIKK2 | Mus musculus | |
additional information | the HO-1 gene is transcriptionally induced by the phorbol ester PMA, mediated via a newly identified kappaB element of the proximal rat HO-1 gene promoter region, overview | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression of the kappaB element of the proximal rat HO-1 gene promoter region, -284 to -275, a nuclear target for the NF-kappaB subunit p65/RelA, expression in in RAW264.7 monocytes fused to the luciferase gene. HO-1 promoter activity is induced by p65, an NF-kappaB subunit, which is also termed RelA, and which is a member of the Rel family of proteins and is activated in response to a variety of stimuli | Mus musculus |
expression of the kappaB element of the proximal rat HO-1 gene promoter region, -284 to -275, a nuclear target for the NF-kappaB subunit p65/RelA, expressionin in RAW264.7 monocytes fused to the luciferase gene | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Mus musculus | HO-1 catalyzes the rate-limiting step of heme degradation and plays an important anti-inflammatory role via its enzymatic products carbon monoxide and biliverdin | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | Rattus norvegicus | HO-1 catalyzes the rate-limiting step of heme degradation and plays an important anti-inflammatory role via its enzymatic products carbon monoxide and biliverdin | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | Mus musculus | PMA-dependent activation of HO-1 is mediated via a nonclassical NF-kappaB pathway that is independent of IKK2 activity | ? | - |
? | |
additional information | Rattus norvegicus | PMA-dependent activation of HO-1 is mediated via a nonclassical NF-kappaB pathway that is independent of IKK2 activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P14901 | - |
- |
Rattus norvegicus | P06762 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
monocyte | - |
Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | HO-1 catalyzes the rate-limiting step of heme degradation and plays an important anti-inflammatory role via its enzymatic products carbon monoxide and biliverdin | Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | HO-1 catalyzes the rate-limiting step of heme degradation and plays an important anti-inflammatory role via its enzymatic products carbon monoxide and biliverdin | Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | PMA-dependent activation of HO-1 is mediated via a nonclassical NF-kappaB pathway that is independent of IKK2 activity | Mus musculus | ? | - |
? | |
additional information | PMA-dependent activation of HO-1 is mediated via a nonclassical NF-kappaB pathway that is independent of IKK2 activity | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Mus musculus |
heme oxygenase-1 | - |
Rattus norvegicus |
HO-1 | - |
Mus musculus |
HO-1 | - |
Rattus norvegicus |