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Literature summary for 1.14.14.18 extracted from

  • Mashreghi, M.F.; Klemz, R.; Knosalla, I.S.; Gerstmayer, B.; Janssen, U.; Buelow, R.; Jozkowicz, A.; Dulak, J.; Volk, H.D.; Kotsch, K.
    Inhibition of dendritic cell maturation and function is independent of heme oxygenase 1 but requires the activation of STAT3 (2008), J. Immunol., 180, 7919-7930.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information cobalt protoporphyrin, CoPPIX, induces the enzyme, molecular mechanism, overview, CoPPIX inhibits STAT3 phosphorylation and the LPS-mediated maturation of bone marrow-derived dendritic cells independently of HO-1 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
sense and antisense constructs, expression analysis in dendritic cells of different maturation levels, cobalt protoporphyrin leads to overexpression of HO-1, molecular mechanism, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information HO-1 knock down by siRNA Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Mus musculus HO-1 shows anti-inflammatory properties biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 Mus musculus C57BL/6 HO-1 shows anti-inflammatory properties biliverdin + Fe2+ + CO + A + H2O
-
?
additional information Mus musculus LPS-induced maturation of dendritic cells is dependent on STAT3 phosphorylation and independent of HO-1 activity, overview ?
-
?
additional information Mus musculus C57BL/6 LPS-induced maturation of dendritic cells is dependent on STAT3 phosphorylation and independent of HO-1 activity, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P14901 C57BL/6 mice
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Mus musculus C57BL/6 P14901 C57BL/6 mice
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Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
Mus musculus
-
dendritic cell bone marrow-derived, mature and immature Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 HO-1 shows anti-inflammatory properties Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2
-
Mus musculus C57BL/6 biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 HO-1 shows anti-inflammatory properties Mus musculus C57BL/6 biliverdin + Fe2+ + CO + A + H2O
-
?
additional information LPS-induced maturation of dendritic cells is dependent on STAT3 phosphorylation and independent of HO-1 activity, overview Mus musculus ?
-
?
additional information LPS-induced maturation of dendritic cells is dependent on STAT3 phosphorylation and independent of HO-1 activity, overview Mus musculus C57BL/6 ?
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase 1
-
Mus musculus
HO-1
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Mus musculus