Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | cobalt protoporphyrin, CoPPIX, induces the enzyme, molecular mechanism, overview, CoPPIX inhibits STAT3 phosphorylation and the LPS-mediated maturation of bone marrow-derived dendritic cells independently of HO-1 | Mus musculus |
Cloned (Comment) | Organism |
---|---|
sense and antisense constructs, expression analysis in dendritic cells of different maturation levels, cobalt protoporphyrin leads to overexpression of HO-1, molecular mechanism, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | HO-1 knock down by siRNA | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Mus musculus | HO-1 shows anti-inflammatory properties | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | Mus musculus C57BL/6 | HO-1 shows anti-inflammatory properties | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | Mus musculus | LPS-induced maturation of dendritic cells is dependent on STAT3 phosphorylation and independent of HO-1 activity, overview | ? | - |
? | |
additional information | Mus musculus C57BL/6 | LPS-induced maturation of dendritic cells is dependent on STAT3 phosphorylation and independent of HO-1 activity, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P14901 | C57BL/6 mice | - |
Mus musculus C57BL/6 | P14901 | C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Mus musculus | - |
dendritic cell | bone marrow-derived, mature and immature | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | HO-1 shows anti-inflammatory properties | Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | - |
Mus musculus C57BL/6 | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | HO-1 shows anti-inflammatory properties | Mus musculus C57BL/6 | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | LPS-induced maturation of dendritic cells is dependent on STAT3 phosphorylation and independent of HO-1 activity, overview | Mus musculus | ? | - |
? | |
additional information | LPS-induced maturation of dendritic cells is dependent on STAT3 phosphorylation and independent of HO-1 activity, overview | Mus musculus C57BL/6 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase 1 | - |
Mus musculus |
HO-1 | - |
Mus musculus |