Literature summary for 1.14.14.18 extracted from

Grion, N.; Repetto, E.M.; Pomeraniec, Y.; Calejman, C.M.; Astort, F.; Sanchez, R.; Pignataro, O.P.; Arias, P.; Cymeryng, C.B.
Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: involvement of both signaling systems in the modulation of ACTH-dependent steroid production (2007), J. Endocrinol., 194, 11-20.

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Activating Compound

Activating Compound	Comment	Organism	Structure
lipopolysaccharide	activates the enzyme, activation is partly reduced by addition of inhibitor Sn-protoporphyrin	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
Sn-protoporphyrin IX	Sn-PPIX, inhibits the enzyme and reduces the activating effect of lipopolysaccharides	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	NO derived from LPS-induced nitric oxide synthase, NOS, entails an increase in HO activity and this activity, in turn, is involved in the consequent inhibition of NOS, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adrenal cortex	constitutive expression of HO-2	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	NO derived from LPS-induced nitric oxide synthase, NOS, entails an increase in HO activity and this activity, in turn, is involved in the consequent inhibition of NOS, overview	Rattus norvegicus	?	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Rattus norvegicus

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Release 2023.1 (January 2023)