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Literature summary for 1.14.14.18 extracted from

  • Sass, G.; Leukel, P.; Schmitz, V.; Raskopf, E.; Ocker, M.; Neureiter, D.; Meissnitzer, M.; Tasika, E.; Tannapfel, A.; Tiegs, G.
    Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice (2008), Int. J. Cancer, 123, 1269-1277.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information inhibition of HO-1 expression by small interfering RNA decreases cellular survival and apoptosis in the mouse hepatoma cell lines Hepa129 and Hepa1-6, and orthotopic tumor growth in immune-competent C3H/HeN mice, mechanism. But application of siHO1 does not induce liver or kidney damage in mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Mus musculus endogenous HO-1 shows anti-apoptotic activity, and is overexpressed in various cancer diseases and might contribute to cancer progression biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 Mus musculus C3H/HEN endogenous HO-1 shows anti-apoptotic activity, and is overexpressed in various cancer diseases and might contribute to cancer progression biliverdin + Fe2+ + CO + A + H2O
-
?
additional information Mus musculus inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic hepatocellular carcinoma and reduced angiogenesis, mechanism, overview ?
-
?
additional information Mus musculus C3H/HEN inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic hepatocellular carcinoma and reduced angiogenesis, mechanism, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P14901 C3H/HeN mice
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Mus musculus C3H/HEN P14901 C3H/HeN mice
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Mus musculus
-
hepatoma cell overexpression of HO-1 Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 endogenous HO-1 shows anti-apoptotic activity, and is overexpressed in various cancer diseases and might contribute to cancer progression Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2
-
Mus musculus C3H/HEN biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 endogenous HO-1 shows anti-apoptotic activity, and is overexpressed in various cancer diseases and might contribute to cancer progression Mus musculus C3H/HEN biliverdin + Fe2+ + CO + A + H2O
-
?
additional information inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic hepatocellular carcinoma and reduced angiogenesis, mechanism, overview Mus musculus ?
-
?
additional information inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic hepatocellular carcinoma and reduced angiogenesis, mechanism, overview Mus musculus C3H/HEN ?
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Mus musculus
HO-1
-
Mus musculus