Literature summary for 1.14.14.18 extracted from

Pae, H.O.; Jeong, G.S.; Jeong, S.O.; Kim, H.S.; Kim, S.A.; Kim, Y.C.; Yoo, S.J.; Kim, H.D.; Chung, H.T.
Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells (2007), Exp. Mol. Med., 39, 267-277.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	curcumin, but not its metabolite tetrahydrocurcumin, induces HO-1 expression and growth inhibition of aortic smooth muscle cells through Nrf2-dependent antioxidant response element, ARE, activation, mechanism, overview, curcumin is isolated from the rhizomes of turmeric	Homo sapiens
additional information	curcumin, but not its metabolite tetrahydrocurcumin, induces HO-1 expression and growth inhibition of vascular smooth muscle cells through Nrf2-dependent antioxidant response element, ARE, activation, mechanism, overview, curcumin is isolated from the rhizomes of turmeric	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
tin protoporphyrin	-	Homo sapiens
tin protoporphyrin	-	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens
Mg2+	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
heme + AH2 + O2	Homo sapiens	in aortic smooth muscle cells, induction of HO-1 confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 that is involved in negative regulation of cellular proliferation, overview	biliverdin + Fe2+ + CO + A + H2O	-	?
heme + AH2 + O2	Rattus norvegicus	in vascular smooth muscle cells, induction of HO-1 confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 that is involved in negative regulation of cellular proliferation, overview	biliverdin + Fe2+ + CO + A + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09601	-	-
Rattus norvegicus	P06762	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aortic smooth muscle cell	-	Homo sapiens	-
vascular smooth muscle cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
heme + AH2 + O2	-	Homo sapiens	biliverdin + Fe2+ + CO + A + H2O	-	?
heme + AH2 + O2	-	Rattus norvegicus	biliverdin + Fe2+ + CO + A + H2O	-	?
heme + AH2 + O2	in aortic smooth muscle cells, induction of HO-1 confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 that is involved in negative regulation of cellular proliferation, overview	Homo sapiens	biliverdin + Fe2+ + CO + A + H2O	-	?
heme + AH2 + O2	in vascular smooth muscle cells, induction of HO-1 confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 that is involved in negative regulation of cellular proliferation, overview	Rattus norvegicus	biliverdin + Fe2+ + CO + A + H2O	-	?

Synonyms

Synonyms	Comment	Organism
heme oxygenase-1	-	Homo sapiens
heme oxygenase-1	-	Rattus norvegicus
HO-1	-	Homo sapiens
HO-1	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens
7.4	-	assay at	Rattus norvegicus

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Release 2023.1 (January 2023)