Protein Variants | Comment | Organism |
---|---|---|
additional information | a clinically relevant polymorphism within the HO-1 promoter critically influences its transcriptional activation by both PPAR isoforms, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tin protoporphyrin | SnPP, specific HO-1 inhibition abrogating the inhibition of COX-2 expression by Wy-14,643 | Homo sapiens | |
zinc protoporphyrin | dose-dependently increases SMC proliferation, induced by either platelet-derived growth factor or 15% fetal bovine serum | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Homo sapiens | HO-1 shows vasculoprotective and anti-inflammatory activity, it is ptionally regulated by peroxisome proliferator-activated receptors PPARalpha and PPARgamma in vascular cells, inhibition of HO-1 enzymatic activity reverses PPAR ligand-mediated inhibition of cell proliferation and expression of cyclooxygenase-2 in vascular smooth muscle cells, overview | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09601 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
smooth muscle cell | - |
Homo sapiens | - |
vascular endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | HO-1 shows vasculoprotective and anti-inflammatory activity, it is ptionally regulated by peroxisome proliferator-activated receptors PPARalpha and PPARgamma in vascular cells, inhibition of HO-1 enzymatic activity reverses PPAR ligand-mediated inhibition of cell proliferation and expression of cyclooxygenase-2 in vascular smooth muscle cells, overview | Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |