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Literature summary for 1.14.14.18 extracted from

  • Vlahakis, J.Z.; Kinobe, R.T.; Bowers, R.J.; Brien, J.F.; Nakatsu, K.; Szarek, W.A.
    Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors (2006), J. Med. Chem., 49, 4437-4441.
    View publication on PubMed
Search for more literature for 1.14.14.18

Inhibitors

Inhibitors Comment Organism Structure
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane IC50: 0.0015 mM Homo sapiens
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane IC50: 0.0008 mM Rattus norvegicus
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane IC50: 0.0026 mM Rattus norvegicus
(2S,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane IC50: 0.02 mM Rattus norvegicus
(2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane IC50: 0.012 mM Rattus norvegicus
2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane IC50: 0.004 mM Rattus norvegicus
2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dithiolane IC50: 0.0047 mM Rattus norvegicus
azalanstat IC50: 0.006 mM Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
 Homo sapiens
Fe2+
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
 Homo sapiens
-
spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + 2 NADPH + 2 H+ + 2 O2
-
 Homo sapiens biliverdin + Fe2+ + CO + 2 NADP+ + H2O
-
 ?
heme + 2 NADPH + 2 H+ + 2 O2
-
 Rattus norvegicus biliverdin + Fe2+ + CO + 2 NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
HO-1
-
 Homo sapiens
HO-1
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens
heme
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008
-
 IC50: 0.0008 mM Rattus norvegicus (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane
0.0015
-
 IC50: 0.0015 mM Homo sapiens (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane
0.0026
-
 IC50: 0.0026 mM Rattus norvegicus (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane
0.004
-
 IC50: 0.004 mM Rattus norvegicus 2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane
0.0047
-
 IC50: 0.0047 mM Rattus norvegicus 2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dithiolane
0.006
-
 IC50: 0.006 mM Rattus norvegicus azalanstat
0.012
-
 IC50: 0.012 mM Rattus norvegicus (2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane
0.02
-
 IC50: 0.02 mM Rattus norvegicus (2S,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane