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Literature summary for 1.14.14.18 extracted from

  • Yasui, Y.; Nakamura, M.; Onda, T.; Uehara, T.; Murata, S.; Matsui, N.; Fukuishi, N.; Akagi, R.; Suematsu, M.; Akagi, M.
    Heme oxygenase-1 inhibits cytokine production by activated mast cells (2007), Biochem. Biophys. Res. Commun., 354, 485-490.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rattus norvegicus
expression in rat basophilic leukemia RBL-2H3 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information rat HO-1 cDNA transfected RBL-2H3 cells show altered cytokine production in response to stimulation with anti-ovalbumin OA serum/OA compared to Mock transfected RBL-2H3 cells. HO-1 inhibits anti-OA serum/OA-induced IL-3 and TNF-alpha production. Inhibition of HO-1 activity by Zn (II) protoporphyrin IX, a specific HO-1 inhibitor, prevents the suppression of TNF-alpha production. The cytokine inhibition by HO-1 is associated with selective suppression of the DNA-binding activity of AP-1 transcription factors, phenotype, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Zn (II) protoporphyrin IX a specific HO-1 inhibitor, inhibition of HO-1 activity by Zn (II) protoporphyrin IX, a specific HO-1 inhibitor, prevents the suppression of TNF-alpha production. The cytokine inhibition by HO-1 is associated with selective suppression of the DNA-binding activity of AP-1 transcription factors Rattus norvegicus
Zn(II) protoporphyrin IX 0.02 mM, potent inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus HO-1 is involved in host defense reactions against various stresses, HO-1 modulates immunocyte activation and functions and suppresses mast cell degranulation, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Rattus norvegicus P06762
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Source Tissue

Source Tissue Comment Organism Textmining
basophilic leukemia cell line
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 Rattus norvegicus
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RBL-2H3 cell
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + electron donor + O2
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 Rattus norvegicus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
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 ?
additional information HO-1 is involved in host defense reactions against various stresses, HO-1 modulates immunocyte activation and functions and suppresses mast cell degranulation, overview Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
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 Rattus norvegicus
HO-1
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 Rattus norvegicus