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Literature summary for 1.14.14.18 extracted from
- Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate. Conformational change of the distal helix during the heme cleavage reaction (2003), J. Biol. Chem., 278, 32352-32358.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with biliverdin-iron chelate | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P06762 | isozyme HO-1 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| protoheme + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O | opened conformation of the heme pocket facilitates sequential product release, first iron, then biliverdin, iron triggers slow dissociation of biliverdin | Rattus norvegicus |
aSynonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HO-1 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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