Literature summary for 1.14.14.17 extracted from

Ha, J.; Kwon, S.; Hwang, J.H.; Park, D.H.; Kim, T.W.; Kang, D.G.; Yu, G.E.; Park, H.C.; An, S.M.; Kim, C.W.
Squalene epoxidase plays a critical role in determining pig meat quality by regulating adipogenesis, myogenesis, and ROS scavengers (2017), Sci. Rep., 7, 16740 .

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Application

Application	Comment	Organism
nutrition	expression of myogenic marker genes (Myog, Myod, and Myh4) and adipogenic marker genes (Pparg, Cebpa, and Adipoq) is substantially downregulated in cells transfected with squalene epoxidase siRNA. mRNA expression levels of ROS scavengers, which affect meat quality by altering protein oxidation processes, are significantly downregulated by squalene epoxidase knockdown	Sus scrofa

Protein Variants

Protein Variants	Comment	Organism
additional information	identification of single nucleotide polymorphism c.2565 G>T in Berkshire pigs. Homozygous GG pigs express more squalene epoxidase mRNA than GT heterozygous and TT homozygous pigs in longissimus dorsi tissue. The single nucleotide polymorphism is associated with several meat quality traits including backfat thickness, carcass weight, meat colour (yellowness), fat composition, and water-holding capacity	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	A7L861	-	-

General Information

General Information	Comment	Organism
physiological function	rates of myogenesis and adipogenesis induced in C2C12 cells and 3T3-L1 cells, respectively, are decreased by squalene epoxidase knockdown. The expression of myogenic marker genes (Myog, Myod, and Myh4) and adipogenic marker genes (Pparg, Cebpa, and Adipoq) is substantially downregulated in cells transfected with squalene epoxidase siRNA. mRNA expression levels of ROS scavengers, which affect meat quality by altering protein oxidation processes, are significantly downregulated by squalene epoxidase knockdown	Sus scrofa

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Release 2023.1 (January 2023)