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Literature summary for 1.14.14.17 extracted from

  • Brown, D.N.; Caffa, I.; Cirmena, G.; Piras, D.; Garuti, A.; Gallo, M.; Alberti, S.; Nencioni, A.; Ballestrero, A.; Zoppoli, G.
    Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer (2016), Sci. Rep., 6, 19435 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine breast, ovarian, and colorectal cancers show the highest copy number-driven gene expression among 8783 cases from 22 cancer types, with breast camcer presenting the strongest one. Squalene epoxidase overexpression is more prevalent in aggressive breast cancer, and is an independent prognostic factor of unfavorable outcome. Squalene epoxidase inhibition results in a copy-dosage correlated decrease in cell viability, and in a noticeable increase in replication time, only in lines with detectable Squalene epoxidase transcript Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UNR6
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Synonyms

Synonyms Comment Organism
Erg1
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 Homo sapiens
SQLE
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 Homo sapiens