Literature summary for 1.14.14.17 extracted from

Chua, N.K.; Howe, V.; Jatana, N.; Thukral, L.; Brown, A.J.
A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis (2017), J. Biol. Chem., 292, 19959-19973 .

Search for more literature for 1.14.14.17

Cloned(Commentary)

Cloned (Comment)	Organism
expression in CHO-7 cell	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
F35A/S37A/L65A/I69A	mutant displays blunted cholesterol regulation	Homo sapiens
L42A	mutant displays blunted cholesterol regulation	Homo sapiens
additional information	a 12-residue region (residues Gln-62Leu-73), is required for cholesterol-mediated turnover	Homo sapiens
S43A	mutant displays normal cholesterol regulation	Homo sapiens
V41A	mutant displays normal cholesterol regulation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UNR6	-	-

Synonyms

Synonyms	Comment	Organism
Erg1	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	enzyme undergoes cholesterol-dependent proteasomal degradation when cholesterol is in excess. The amphipathic helix within the first 100 amino acids of squalene monooxygenase attaches reversibly to the ER membrane depending on cholesterol levels. With excess, the helix is ejected and unravels, exposing a hydrophobic patch, which then serves as a degradation signal	Homo sapiens

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Release 2023.1 (January 2023)